助理教授 陽明大學 醫學生物技檢驗學系(2012.8~2017.7)

博士後研究  Terry Fox Laboratory, BC Cancer Agency, Canada (2011.7~2012.7)

博士後研究  Department of Microbiology and Immunology, University of British Columbia, Canada (2008.11~2011.6)

博士後研究 台灣大學 生化科學所 (2008.2~2008.10)

       自然殺手細胞屬於免疫系統中非專一性防禦系統，負責毒殺受感染細胞和腫瘤細胞。其藉由表面的活化型和抑制型接受器與目標細胞上的ligand結合，此結合可分別誘發活化或抑制性訊號，此兩者訊號的強弱調控其毒殺活性。

探討:

1. 自然殺手細胞對白血病細胞以及癌症細胞的毒殺作用機轉
2. 癌細胞躲避免疫監測系統中自然殺手細胞毒殺作用的機轉
3. 細胞表面醣結構的變化對自然殺手細胞表面接受器的辨識及毒殺功能的影響

1. Lee YH, Liao YJ, Huang CH, Chang FL, Fan TH, and Twu YC*. 2017. Branched I antigens on leukemia cells enhanced sensitivity against NK cytotoxicity through affecting the target-effector interaction. Transfusion 57: 1040-1051
2. Liao YJ, Lee YH, Chang FL, Ho H, Huang CH, and Twu YC*. 2016. The SHP-2-ERK2 signaling pathway regulates branched I antigen formation by controlling the binding of C/EBPa to the IGnTC promoter region during erythroid differentiation. Transfusion 56: 2691-2702
3. Liao YJ, Lee TS, Twu YC, Hsu SM, Yang CP, Wang CK, Liang YC and Chen YM. 2016 Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes glconeogenesis by modulating the PI3K/Akt pathway in the liver. Journal of Biomedical Science 23: 69-
4. Twu YC, Lee TS, Lin YL, Hsu SM, Wang YH, Liao CY, Wang CK, Liang YC and Liao YJ. 2016. Niemann-Pick type C2 protein mediates hepatic stellate cells activation by regulating free cholesterol accumulation. International Journal of Molecular Science 17: 1-12
5. Twu YC*, Teh HS. 2014. The ThPOK transcription factor differentially affects the development and function of self-specific CD8+ T cells and regulatory CD4+ T cells. Immunology 141:431-445
6. Twu YC, Gold MR, Teh HS. 2011. TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8(+) T cells. European Journal of Immunology 41: 335- 344
7. Twu YC, Hsieh CY, Lin M, Tzeng CH, Sun CF, Yu LC. 2010. Phosphorylation status of transcription factor C/EBPalpha determines cell-surface poly-LacNAc branching (I antigen) formation in erythropoiesis and granulopoiesis. Blood 115: 2491-2499
8. Wang HR, Hsieh CY, Twu YC, Yu LC. 2008. Expression of the human Sd(a) beta-1,4-N- acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status. Glycobiology 18: 104-113
9. Twu YC, Chen CP, Hsieh CY, Tzeng CH, Sun CF, Wang SH, Chang MS, Yu LC. 2007. I branching formation in erythroid differentiation is regulated by transcription factor C/EBPalpha. Blood 110: 4526-4534
10. Twu YC, Hsieh CY, Yu LC. 2006. Expression of the histo-blood group B gene predominates in AB- genotype cells. Transfusion 46: 1988-1996
11. Lin M, Hou MJ, Twu YC, Yu LC. 2005. A novel A allele with 664G>A mutation identified in a family with the Am phenotype. Transfusion 45: 63-69
12. Yu LC, Twu YC, Chou ML, Reid ME, Gray AR, Moulds JM, Chang CY, Lin M. 2003. The molecular genetics of the human I locus and molecular background explain the partial association of the adult i phenotype with congenital cataracts. Blood 101: 2081-2088
13. Twu YC, Chou ML, Yu LC. 2003. The molecular genetics of the mouse I beta-1,6-N- acetylglucosaminyltransferase locus. Biochemical Biophysical Research Communications 303: 868-876
14. Sun CF, Yu LC, Chen IP, Chou DL, Twu YC, Wang WT, Lin M. 2003. Molecular genetic analysis for the Ae1 and A3 alleles. Transfusion 43: 1138-1144
15. Yu LC, Twu YC, Chou ML, Chang CY, Wu CY, Lin M. 2002. Molecular genetic analysis for the B(3) allele. Blood 100: 1490-2
16. Yu LC, Twu YC, Chang CY, Lin M. 2001. Molecular basis of the Kell-null phenotype: a mutation at the splice site of human KEL gene abolishes the expression of Kell blood group antigens. Journal of Biological Chemistry 276: 10247-10252
17. Yu LC, Twu YC, Chang CY, Lin M. 2001. Molecular basis of the adult i phenotype and the gene responsible for the expression of the human blood group I antigen. Blood 98: 3840-3845
18. Yu LC, Chu CC, Chan YS, Chang CY, Twu YC, Lee HL, Lin M. 2001. Polymorphism and distribution of the Secretor alpha(1,2)-fucosyltransferase gene in various Taiwanese populations. Transfusion 41: 1279-1284
19. Yu LC, Chang CY, Twu YC, Lin M. 2000. Human histo-blood group ABO glycosyltransferase genes: different enhancer structures with different transcriptional activities. Biochemical Biophysical Research Communications 273: 459-466
20. Hsu HY, Twu YC. 2000. Tumor necrosis factor-alpha -mediated protein kinases in regulation of scavenger receptor and foam cell formation on macrophage. Journal of Biological Chemistry 275: 41035-41048