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系所資訊
生技產業創新創業人才培育課程

系所行事曆
楊翠青

 

楊翠青Tsuey-Ching Yang

職稱: 教授

專長:分子細菌學

血液學

   

聯絡方式
Institute of Biotechnology in Medicine, National Yang Ming University, No. 155, Sec. 2, Linong St., Beitou District, Taipei City 112, Taiwan (R.O.C.)

Phone: 02-2826-7289 (Office); 02-2826-7000 5864 (Lab)

E-mail: tcyang@ym.edu.tw

 

學歷
1999 - 2003 National Chung-Hsing University, Taiwan, Ph.D.

1987 - 1989 National Taiwan University, Taiwan M. S.
1983 - 1987 National Taiwan University, Taiwan B. S.


經歷

2011-present Professor, Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University

2009-2011 Professor, Department of Medical Laboratory Science and Biotechnology, China Medical University

2004-2009 Associate Professor, Department of Medical Laboratory Science and Biotechnology, China Medical University

1989-1991, 1995-2004 Lecturer, Department of Medical Laboratory Science and Biotechnology, China Medical University

 

 

研究興趣

  1. Stenotrophomonas maltophilia 抗藥性之盛行率及其機制
  2. Stenotrophomonas maltophilia 壓力調適反應及其機制

 

 

發表論文

  1. Yi-Wei Huang, Hsin-Hui Huang, Kai-Hung Huang, Wei-Chien Chen, Yi-Tsung Lin, Cheng-Chih Hsu, and Tsuey-Ching Yang* (2019) AmpI functions as an iron exporter to alleviate b-lactam-mediated ROS stress in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy. 63:e02467-18. (Corresponding author)
  2. Hsin-Hui Huang, Peng-Ying Chen, Rouh-Mei Hu, Yi-Tsung Lin, Li-Hua Li, Tsuey-Ching Yang*. (2018) The impacts of L1 promoter variation and L2 clavulanate susceptibility on ticarcillin-clavulanate susceptibility of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy. 62:e01222-18. (Corresponding author)
  3. Hsin-Hui Huang, Yi-Tsung Lin, Peng-Ying Chen, Li-Hua Li, Hsiao-Chen Ning, Tsuey-Ching Yang*. (2018) ClpA and HtpX proteases are involved in intrinsic aminoglycoside resistance of Stenotrophomonas maltophilia and are potential aminoglycoside adjuvant targets. Antimicrobial Agents and Chemotherapy. 62: e00554-18. (Corresponding author)
  4. Chao-Jung Wu, Tsu-Ting Chiu, Yi-Tsung Lin, Yi-Wei Huang, Li-Hua Li, Tsuey-Ching Yang*. (2018) Role of smeU1VWU2X operon in the alleviation of oxidative stresses and the occurrence of sulfamethoxazole/trimethoprim-resistant mutants in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 62:e02114-17. (Corresponding author)
  5. Ying-Hsiu Lin, Tsuey-Ching Yang*, Wensi S. Hu*. (2018) Characterization of stm3030 and stm3031 genes of Salmonella enterica serovar Typhimurium in relation to cephalosporin resistance. Journal of Microbiology, Immunology, and Infection. pii: S1684-1182(18)30413-4. (Corresponding author)
  6. Yi-Tsung Lin*, Yi-Hsiang Cheng, Chih-Han Juan, Ping-Feng Wu, Yi-Wei Huang, Sheng-Hua Chou, Tsuey-Ching Yang, Fu-Der Wang. (2018) High mortality among patients infected with hypervirulent antimicrobial-resistant capsular type K1 Klebsiella pneumoniae strains in Taiwan. International Journal of Antimicrobials Agents. 52:251-257.
  7. Yen-Hua Huaang, Sheng-Hua Chou, Syun-Wun Liang, Chung-En Ni, Yi-Tsung Lin*, Yi-Wei Huang, Tsucy-Ching Yang. (2018) Emergence of an XDR and carbapenemase-producing hypervirulent Klebsiella pneumoniae strain in Taiwan. Journal of Antimicrobial Chemotherapy. 73:2039-2046.
  8. Ping-Feng Wu, Yi-Tsung Lin*, Fu-Der Wang, Tsuey-Ching Yang, Chang-phone Fung. (2018) Is fluoroquinolone monotherapy a useful alternative treatment for Pseudomonas aeruginosa bacteraemia? Infection. 46:365-373.
  9. Yi-Wei Huang, Yu Wang, Yun Lin, Chin Lin, Yi-Tsung Lin, Cheng-Chih Hsu*, Tsuey-Ching Yang*. (2017) Impacts of penicillin binding protein 2 inactivation on b-lactamase expression and muropeptide profile in Stenotrophomonas maltophilia. mSystems. 2:e00077-17. (Corresponding author)
  10. Yi-Wei Huang, Cheng-Wen Lin, Hsiao-Chen Ning, Yi-Tsung Lin, Yi-Chih Chang, Tsuey-Ching Yang*. (2017) Overexpression of SmeDEF efflux pump decreases aminoglycoside resistance in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 61:e02685-16. (Corresponding author)
  11. Hsin-Hui Huang, Wei-Ching Chen, Cheng-Wen Lin, Yi-Tsung Lin, Hsiao-Chen Ning, Yi-Chih Chang, Tsuey-Ching Yang*. (2017) Relationship of the CreBC two-component regulatory system and inner membrane protein CreD with swimming motility in Stenotrophomonas maltophilia. PLoS One 12:e0174707. (Corresponding author)
  12. Chao-Jung Wu, Yi-Wei Huang, Yi-Tsung Lin, Tsuey-Ching Yang*. (2016) Inactivation of lytic transglycosylases increases susceptibility to aminoglycosides and macrolides by altering the outer membrane permeability of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 60:3236-3239. (Corresponding author)
  13.  Chao-Jung Wu, Yi-Wei Huang, Yi-Tsung Lin, Hsiao-Chen Ning, Tsuey-Ching Yang*. (2016) Inactivation of SmeSyRy two-component regulatory System inversely regulates the expression of SmeYZ and SmeDEF efflux pumps in Stenotrophomonas maltophilia. PLoS One 11:e0160943. (Corresponding author)
  14. Shih-Wein Lin, Ching-Ying Yang, Yu-Jen Jou, Tsuey-Ching Yang, Su-Hua Huang, Lei Wan, Ying-Ju Lin, Cheng-Wen Lin. (2016) SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway. Scientific Reports 13;6:25754.
  15. Chih-Han Juan, Yi-Wei Huang, Yi-Tsung Lin, Tsuey-Ching Yang, Fu-Der Wang. (2016) Risk factors, outcomes, and mechanisms of tigecycline-nonsusceptible Klebsiella pneumoniae bacteremia. Antimicrobial Agents and Chemotherapy 60:7357-7363.
  16. Yi-Tsung Lin, Yi-Wei Huang, Hsin-Hui Huang, Tsuey-Ching Yang, Fu-Der Wang, Chang-Fung Fung. (2016) In vivo evolution of tigecycline-non-susceptible Klebsiella pneumoniae strains in patients: relationship between virulence and resistance. International Journal of Antimicrobial Agents 48:485-491.
  17. Yi-Wei Huang, Chao-Jung Wu, Rouh-Mei Hu, Yi-Tsung Lin, Tsuey-Ching Yang*. (2015) Interplay among membrane-bound lytic transglycosylase D1, the CreBC two-component regulatory system, the AmpNG-AmpDI-NagZ-AmpR regulatory circuit, and L1/L2 beta-lactamase expression in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 59:6866-6872. (Corresponding author)
  18. Yi-Tsung Lin, Yi-Wei Huang, Shiang-Jiuun Chen, Chia-Wei Chang, Tsuey-Ching Yang*. (2015) The SmeYZ efflux pump of Stenotrophomonas maltophilia contributes to drug resistance, virulence-related characteristics, and virulence in mice. Antimicrobial Agents and Chemotherapy 59:4067-4073. (Corresponding author)
  19. Hsin-Hui Huang, Yi-Tsung Lin, Wei-Ching Chen, Yi-Wei Huang, Shiang-Jiuun Chen, Tsuey-Ching Yang*. (2015) Expression and functions of CreD, an inner membrane protein in Stenotrophomonas maltophilia. PLoS One 10:e0145009. (Corresponding author)
  20. Yi-Wei Huang, Rouh-Mei Hu, Yi-Tsung Lin, Hsin-Hui Huang, Tsuey-Ching Yang*. (2015) The contribution of class 1 integron to antimicrobial resistance in Stenotrophomonas maltophilia. Microbial Drug Resistance 21:90-96. (Corresponding author)
  21. Yi-Wei Huang, Rung-Shiuan Liou, Yi-Tsung Lin, Hsin-Hui Huang, Tsuey-Ching Yang*. (2014) A linkage between SmeIJK efflux pump, cell envelope integrity, and sigma s-mediated envelope stress response in Stenotrophomonas maltophilia. PLoS One 9:e111784. (Corresponding author)
  22. Yi-Tsung Lin, Yi-Wei Huang, Rung-ShiuanLiou, Yi-Chih Chang, Tsuey-Ching Yang*. (2014) MacABCsm, an ABC-type tripartite efflux pump of Stenotrophomonas maltophilia involved in drug resistance, oxidative and envelope stress tolerances and biofilm formation. Journal of Antimicrobial Chemotherapy 69:3221-3226. (Corresponding author)
  23. Cheng-Wen Lin, Yi-Wei Huang, Rouh-Mei Hu, Tsuey-Ching Yang*. (2014) SmeOP-TolCsm efflux pump contributes to multidrug resistance of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 58:2405-2408. (Corresponding author)
  24. Shih-Wen Li, Tsuey-Ching Yang, Chien-Chen Lai, Su-Hua Huang, Jun-Ming Liao, Lei Wan, Ying-Ju Lin, Cheng-Wei Lin. (2014) Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation. European Journal of Pharmacology 738:125-132.
  25. Tsuey-Ching Yang, Tzu-Fan Chen, Jeffrey J. P. Tsai, Rouh-Mei Hu. (2014) NagZ is required for beta-lactamase expression and full pathogenicity in Xanthomonas campestris pv. campestris str 17. Research in Microbiology 165:612-619. (First author)
  26. Yi-Wei Huang, Rouh-Mei Hu, Fang-Yeh Chu, Hui-Rung Lin, Tsuey-Ching Yang*. (2013) Characterization of a major facilitator superfamily (MFS) tripartite efflux pump EmrCABsm from Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy 68: 2498-2505. (Corresponding author)
  27. Yi-Wei Huang, Rouh-Mei Hu, Tsuey-Ching Yang*. (2013) Role of the pcm-tolCsm operon in the multidrug resistance of Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy 68: 1987-1993. (Corresponding author)
  28. Tsuey-Ching Yang, Shih-Wein Li, Chien-Chen Lai, Kai-Zen Lu, Man-Tzu Chiu, Tsung-Ham Hsieh, Lei Wan, Cheng-Wen Lin*. (2013) Proteomic analysis for Type I interferon antagonism of Japanese encephalitis virus NS5 protein. Proteomics 13:3442-3456. (First author)
  29. Tsuey-Ching Yang, Tzu-Fan Chen, Jeffrey J. P. Tsai, Rouh-Mei Hu. (2013) AmpG is required for BlaXc beta-lactamase expression in Xanthomonas campestris pv. campestris str. 17. FEMS Microbiology Letters 340:101-108. (First author)
  30. Rouh-Mei Hu, Sih-Ting Liao, Chiang-Ching Huang, Yi-Wei Huang, Tsuey-Ching Yang*. (2012) An inducible fusaric acid tripartite efflux pump contributes to the fusaric acid resistance in Stenotrophomonas maltophilia. PLoS One 7:e51053. (Corresponding author)
  31. Yi-Wei Huang, Rouh-Mei Hu, Cheng-Wen Lin, Tung-Ching Chung, Tsuey-Ching Yang*. (2012) NagZ-dependent and NagZ-independent mechanisms for the b-lactamases expression in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 56:1936-1941. (Corresponding author)
  32. Shih-Wen Li, Tsuey-Ching Yang, Lei Wan, Ying-Ju Lin, Fuu-Jen Tsai, Chien-Chen Lai, Cheng-Wen Lin*. (2012) Correlation between TGF-b1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease. Proteomics 12:3193-3205.
  33. Tsuey-Ching Yang, David Hecht, Jeffrey J. P. Tsai, Rouh-Mei Hu*. (2012) Cefoxitin is both an inhibitor of class A beta-lactamase of Xanthomonas cempestris pv. campestris str. 17 and an inducer of its gene. Research in Microbiology 163:550-556. (First author)
  34. Chao-Hsien Chen, Chiang-Ching Huang, Tsao-Chuen Chung, Rouh-Mei Hu, Yi-Wei Huang, Tsuey-Ching Yang*. (2011) Contribution of resistance-nodulation-division efflux pump operon smeU1-V-W-U2-X to multidrug resistance of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 55:5826-5833. (Corresponding author)
  35. Cheng-Wen Lin, Hsin-Chieh Lin, Yi-Wei Huang, Tung-Ching Chung, Tsuey-Ching Yang*. (2011) Inactivation of mrcA gene derepresses the basal-level expression of L1 and L2 beta-lactamases in Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy 66:2033-2037. (Corresponding author)
  36. Yi-Chin Chang, Mei-Jung Tsai, Yi-Wei Huang, Tung-Ching Chung, Tsuey-Ching Yang*. (2011) SmQnrR, a DeoR-type transcriptional regulator, negatively regulates the expression of Smqnr and SmtcrA in Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy 66:1024-1028. (Corresponding author)
  37. Tsuey-Ching Yang, Me-Jung Tsai, Jeffrey, J. P. Tsai, Rouh-Mei Hu*. (2011) Induction of a secretable beta-lactamase requires a long lag time in Xanthomonas campestris pv. Campestris str. 17. Research in Microbiology 162:999-1005. (First author)
  38. Yi-Wei Huang, Rouh-Mei Hu, Yu-Ting Chiang, Tsao-Chuen Chung, Tung-Ching Chung, Tsuey-Ching Yang*. (2011) Establishment of an arabinose-inducible system in Stenotrophomonas maltophilia. Folia Microbiologica 56:18-22. (Corresponding author)
  39. Yi-Wei Huang, Cheng-Wen Lin, Rouh-Mei Hu, Yu-Tzu Lin, Tung-Ching Chung, Tsuey-Ching Yang*. (2010) An AmpN-AmpG operon is essential for the expression of L1 and L2 beta-lactamases in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 54:2583-2589. (Corresponding author)
  40. Yi-Chih Chang, Yi-Wei Huang, Kai-Hung Chiang, Tsuey-Ching Yang*, Tung-Ching Chung*. (2010) Introduction of an AmpR-L2 intergenic segment attenuates the induced beta-lactamase activity of Stenotrophomonas maltophilia. European Journal of Clinical Microbiology and Infectious Disease 29:887-890. (Corresponding author)
  41.  Tsuey-Ching Yang, Chien-Chen Lai, Su-LianShiu, Pei-Hsin Chuang, Bo-Cheng Tzou, Ying-Ya Lin, Fuu-Jen Tsai, Cheng-Wen Lin*. (2010) Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38MAPK activation in human promonocyte cells. Microbes and Infection 12:643-651. (First author)
  42. Ping-Ning Hsu*, Tsuey-Ching Yang*, Jung-Ta Kao, Ken-Sheng Cheng, Yi-Ju Lee, Yuan-Min Wang, Chin-Tung Hsieh, Cheng-Wen Lin, Yi-Ying Wu*. (2010) Increased PD-1 and decreased CD28 expression in chronic hepatitis B patients with advanced hepatocellular carcinoma. Liver International 30:1379-1386. (Corresponding author)
  43. Nai-Wan Hsiao, Jiun-Wei Chen, Tsuey-Ching Yang, Gregg M. Orloff, Yi-Ying Wu, Chih-Ho Lai, Yu-Ching Lan, Cheng-Wen Lin*. (2010) ISG15 over-expression inhibits the replication of Japanese encephalitis virus in human medulloblastoma cells. Antiviral Research 85:504-511.
  44. Tsuey-Ching Yang*, Yi-Wei Huang, Rouh-Mei Hu, Shao-Cheng Huang, and Yu-Tzu Lin. (2009) AmpDI is involved in expression of chromosomal L1 and L2 b-lactamases of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 53:2902-2907. (Corresponding author)
  45. Tsuey-Ching Yang, Yu-Wei Leu, Hui-Chen Chang-Chien, Rouh-Medi Hu*. (2009) Flagellar biogenesis of Xanthomonas campestris requires alternative sigma factors RpoN2 and FliA, and temporally regulated by FlhA, FlhB and FlgM. Journal of Bacteriology 191:2266-2275. (First author)
  46. Cheng-Wen Lin, Yi-Wei Huang, Rouh-Mei Hu, Kai-Hung Chiang, Tsuey-ChingYang*. (2009) The role of AmpR in the regulation of L1 and L2 beta-lactamases in Stenotrophomonas maltophilia. Research in Microbiology 160:152-158. (Corresponding author)
  47. Rouh-Mei Hu, Kai-Hung Chiang, Yi-Chih Chang, Tsuey-Ching Yang*. (2009) Characterization of the charge variants of L2 beta-lactamase in Stenotrophomonas maltophilia. Journal of Medical Microbiology 58:318-321. (Corresponding author)
  48. Tsuey-Ching Yang, Chun-Pin Chang, Yu-Ching Lan, Chao-Li Liu, Mu-Chin Shih, Fang-Yang Wu, Cheng-Wen Lin. (2009) Recombinant ORF66 and ORFK12 antigens for the detection of human herpesvirus 8 antibodies in HIV-positive and –negative patients. Biotechnology Letters 31:629-637. (First author)
  49. Tsuey-Ching Yang, Su-Lian Shiu, Pei-Hsin Chuang, Ying-Ju Lin, Lei Wan,Yu-Ching Lan, Cheng-Wen Lin*. (2009) Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells. Virus Research 143:77-85. (First author)
  50. Rouh-Mei Hu, Kuang-Jay Huang, Lii-Tzu Wu, Ying-Ju Hsiao, Tsuey-Ching Yang*. (2008) Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy. 52:1198-1200. (Corresponding author)
  51. Su-Hua Huang, Tsuey-Ching Yang, Ming-Hong Tsai, I-ShouTasi, Huang-ChihLu, Pei-Hsin Chuang, Lei-Wan, Ying-Ju Lin, Chih-Ho Lai, and Cheng-Wen Lin. (2008) Gold nanoparticle-based RT-PCR and real-time quantitative RT-PCR assays for detection of Japanese encephalitis virus. Nanotechnology. 19:pp405101.
  52. Cheng-Wen Lin, Rouh-Mei Hu, Shao-Cheng Huang, Ying-Ju Hsiao, Tsuey-Ching Yang*. (2008) Induction potential of clavulanic acid toward L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. European Journal of Clinical Microbiology & Infectious Disease 27:1273-1275. (Corresponding author)
  53. Rouh-Mei Hu, Kai-Hung Chiang, Cheng-Wen Lin, Tsuey-Ching Yang*. (2008) Modified nitrocefin-EDTA method to differentially quantify the induced L1 and L2 beta-lactamase in Stenotrophomonas maltophilia. Letters in Applied Microbiology 47:457-461. (Corresponding author)
  54. Cheng-Wen Lin, Chien-Shun Chiou, Yi-Chih Chang, Tsuey-Ching Yang*. (2008) Comparison of pulsed-field gel electrophoresis and three rep-PCR methods for evaluating the genetic relatedness of Stenotrophomonas maltophiliaisolates. Letters in Applied Microbiology 47:393-398. (Corresponding author)
  55. Cheng-Wen Lin*, Chieh-Wen Cheng, Tsuey-Ching Yang, Shih-Wein Li, Mei-Hsiu Cheng, Lei Wan, Ying-Ju Lin, Chih-Ho Lai, Wei-Yong Lin, Ming-Ching Kao. (2008) Interferon antagonist function of Japanese encephalitisvirus NS4A and its interaction with DEAD-box RNA helicase DDX42. Virus Research 137:49-55.
  56. Yi-Ming Hsiao, Mei-Huei Zheng, Rouh-Mei Hu, Tsuey-Ching Yang, Yi-Hsiung Tseng*. (2008) Regulation of pehA gene encoding the major polygalacturonase of Xanthomonas campestris by Clp and RpfF. Microbiology-SGM 154:705-713.
  57. Tsuey-Ching Yang, Rouh-Mei Hu, Shu-Fu Weng, and Yi-Hsiung Tseng*. (2007) Identification of a hypothetical protein of plant pathogenic Xanthomonas campestrisas a novel beta-galactosidase. Journal of Molecular Microbiology and Biotechnology 13:172-180.
  58. Lii-Tzu Wu, Shu-Ying Chang, Ming-Ren Yen, Tsuey-Ching Yang, Yi-Hsiung Tseng*. (2007) Characterization of extended-host-range pseudo-T-even bacteriophage Kpp95 isolated on Klebsiella pneumoniae. Applied and Environmental Microbiology 73:2532-2540.
  59. Rouh-Mei Hu, Tsuey-ChingYang, Shu-Hui Yang, Yi-Hsiung Tseng*. (2005) Deduction of upstream sequence of Xanthomonas campestris flagellar genes responding to transcription activation byFleQ. Biochemical and Biophysical Research Communications 335:1035-1043.
  60. Yi-Min Hsiao, Hsiu-Ying Liao, Mong-Chuan Lee, Tsuey-Ching Yang, Yi-Hsiung Tseng*. (2005) Clp upregulates transcription of engA gene encoding a virulence factor in Xanthomonas campestris by direct binding to the upstream tandem Clp sites. FEBS Letters 579:3525-3533.
  61. Tsuey-Ching Yang, Rouh-Mei Hu, Yi-Min Hsiao, Shu-Fen Weng, Yi-Hsiung Tseng*. (2003) Molecular genetic analyses of potential b-galactosidase genes in Xanthomonas campestris. Journal of Molecular Microbiology and Biotechnology 6:145-154. (First author)
  62. Tsuey-Ching Yang, Gong-Ho Wu, Yi-Hsiung Tseng*. (2002) Isolation of a Xanthomonas campestris strain with elevated b-galactosidase activity for direct use of lactose in xanthan gum production. Letters in Applied Microbiology 35:375-379.

 

  1. Yi-Wei Huang, Yu Wang, Yun Lin, Chin Lin, Yi-Tsung Lin, Cheng-CHih Hsu, Tsuey-Ching Yang*. 2017. Impacts of penicillin binding protein 2 inactivation on β-lactamases expression and muropeptides profile in Stenotrophomonas maltophilia. mSystems (accepted)
  2. Hsin-Hui Huang, Wei-Ching Chen, Cheng-Wen Lin, Yi-Tsung Lin, Hsiao-Chen Ning, Yi-Chih Chang, Tsuey-Ching Yang*. 2017. Relationship of the CreBC two-component regulatory system and inner membrane protein CreD with swimming motility in Stenotrophomonas maltophilia. PLoS ONE 12:e0174704 (Corresponding author)
  3. Yi-Wei Huang, Cheng-Wen Lin, Hsiao-Chen Ning, Yi-Tsung Lin, Yi-Chih Chang, Tsuey-Ching Yang*. 2017. Overexpression of SmeDEF efflux pump decreases aminoglycoside resistance in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 61:e02685-16 (Corresponding author)
  4. Chao-Jung Wu, Yi-Wei Huang, Yi-Tsung Lin, Tsuey-Ching Yang*. 2016.  Inactivation of lytic transglycosylases increases susceptibility to aminoglycosides and macrolides by altering the outer membrane permeability of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 60:3236-3239. (Corresponding author)
  5. Chao-Jung Wu, Yi-Wei Huang, Yi-Tsung Lin, Hsiao-Chen Ning, Tsuey-Ching Yang*. 2016. Inactivation of SmeSyRy two-component regulatory System inversely regulates the expression of SmeYZ and SmeDEF efflux pumps in Stenotrophomonas maltophilia. PLoS One 11:e0160943. (Corresponding author)
  6. Shih-Wein Lin, Ching-Ying Yang, Yu-Jen Jou, Tsuey-Ching Yang, Su-Hua Huang, Lei Wan, Ying-Ju Lin, Cheng-Wen Lin. 2016. SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway. Scientific Reports 13;6:25754.
  7. Chih-Han Juan, Yi-Wei Huang, Yi-Tsung Lin, Tsuey-Ching Yang, Fu-Der Wang. 2016. Risk factors, outcomes, and mechanisms of tigecycline-nonsusceptible Klebsiella pneumoniae bacteremia. Antimicrobial Agents and Chemotherapy 60:7357-7363.
  8. Yi-Tsung Lin, Yi-Wei Huang, Hsin-Hui Huang, Tsuey-Ching Yang, Fu-Der Wang, Chang-Fung Fung. 2016. In vivo evolution of tigecycline-non-susceptible Klebsiella pneumoniae strains in patients: relationship between virulence and resistance. International Journal of Antimicrobial Agents 48:485-491.
  9. Yi-Wei Huang, Chao-Jung Wu, Rouh-Mei Hu, Yi-Tsung Lin, Tsuey-Ching Yang*. 2015. Interplay among membrane-bound lytic transglycosylase D1, the CreBC two-component regulatory system, the AmpNG-AmpDI-NagZ-AmpR regulatory circuit, and L1/L2 beta-lactamase expression in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 59:6866-6872. (Corresponding author)
  10. Yi-Tsung Lin, Yi-Wei Huang, Shiang-Jiuun Chen, Chia-Wei Chang, Tsuey-Ching Yang*. 2015. The SmeYZ efflux pump of Stenotrophomonas maltophilia contributes to drug resistance, virulence-related characteristics, and virulence in mice. Antimicrobial Agents and Chemotherapy 59:4067-4073. (Corresponding author)
  11. Hsin-Hui Huang, Yi-Tsung Lin, Wei-Ching Chen, Yi-Wei Huang, Shiang-Jiuun Chen, Tsuey-Ching Yang*. 2015. Expression and functions of CreD, an inner membrane protein in Stenotrophomonas maltophilia. PLoS One 10:e0145009. (Corresponding author)
  12. Yi-Wei Huang, Rouh-Mei Hu, Yi-Tsung Lin, Hsin-Hui Huang, Tsuey-Ching Yang*. 2015. The contribution of class 1 integron to antimicrobial resistance in Stenotrophomonas maltophilia. Microbial Drug Resistance 21:90-96. (Corresponding author)
  13. Yi-Wei Huang, Rung-Shiuan Liou, Yi-Tsung Lin, Hsin-Hui Huang, Tsuey-Ching Yang*. 2014. A linkage between SmeIJK efflux pump, cell envelope integrity, and sigma s-mediated envelope stress response in Stenotrophomonas maltophilia. PLoS One 9:e111784. (Correspondingauthor)
  14. Yi-Tsung Lin, Yi-Wei Huang, Rung-ShiuanLiou, Yi-Chih Chang, Tsuey-Ching Yang*. 2014. MacABCsm, an ABC-type tripartite efflux pump of Stenotrophomonas maltophilia involved in drug resistance, oxidative and envelope stress tolerances and biofilm formation. Journal of Antimicrobial Chemotherapy 69:3221-3226. (Corresponding author)
  15. Cheng-Wen Lin, Yi-Wei Huang, Rouh-Mei Hu, Tsuey-Ching Yang*. 2014. SmeOP-TolCsm efflux pump contributes to multidrug resistance of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 58:2405-2408. (Corresponding author)
  16. Shih-Wen Li, Tsuey-Ching Yang, Chien-Chen Lai, Su-Hua Huang, Jun-Ming Liao, Lei Wan, Ying-Ju Lin, Cheng-Wei Lin. 2014. Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation. European Journal of Pharmacology 738:125-132.
  17. Tsuey-Ching Yang, Tzu-Fan Chen, Jeffrey J. P. Tsai, Rouh-Mei Hu. 2014. NagZ is required for beta-lactamase expression and full pathogenicity in Xanthomonas campestris pv. campestris str 17. Research in Microbiology 165:612-619. (First author)
  18. Yi-Wei Huang, Rouh-Mei Hu, Fang-Yeh Chu, Hui-Rung Lin, Tsuey-Ching Yang*. 2013. Characterization of a major facilitator superfamily (MFS) tripartite efflux pump EmrCABsm from Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy 68: 2498-2505. (Corresponding author)
  19. Yi-Wei Huang, Rouh-Mei Hu, Tsuey-Ching Yang*. 2013. Role of the pcm-tolCsm operon in the multidrug resistance of Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy 68: 1987-1993. (Corresponding author)
  20. Tsuey-Ching Yang, Shih-Wein Li, Chien-Chen Lai, Kai-Zen Lu, Man-Tzu Chiu, Tsung-Ham Hsieh, Lei Wan, Cheng-Wen Lin*. 2013. Proteomic analysis for Type I interferon antagonism of Japanese encephalitis virus NS5 protein. Proteomics 13:3442-3456. (First author)
  21. Tsuey-Ching Yang, Tzu-Fan Chen, Jeffrey J. P. Tsai, Rouh-Mei Hu. 2013. AmpG is required for BlaXc beta-lactamase expression in Xanthomonas campestris pv. campestris str. 17. FEMS Microbiology Letters 340:101-108. (First author)
  22. Rouh-Mei Hu, Sih-Ting Liao, Chiang-Ching Huang, Yi-Wei Huang, Tsuey-Ching Yang*. 2012. An inducible fusaric acid tripartite efflux pump contributes to the fusaric acid resistance in Stenotrophomonas maltophilia. PLoS One 7:e51053. (Corresponding author)
  23. Yi-Wei Huang, Rouh-Mei Hu, Cheng-Wen Lin, Tung-Ching Chung, Tsuey-Ching Yang*. 2012. NagZ-dependent and NagZ-independent mechanisms for the b-lactamases expression in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 56:1936-1941. (Corresponding author)
  24. Shih-Wen Li, Tsuey-Ching Yang, Lei Wan, Ying-Ju Lin, Fuu-Jen Tsai, Chien-Chen Lai, Cheng-Wen Lin*. 2012. Correlation between TGF-1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease. Proteomics 12:3193-3205.
  25. Tsuey-Ching Yang, David Hecht, Jeffrey J. P. Tsai, Rouh-Mei Hu*. 2012. Cefoxitin is both an inhibitor of class A beta-lactamase of Xanthomonas cempestris pv. campestris str. 17 and an inducer of its gene. Research in Microbiology 163:550-556. (First author)
  26. Chao-Hsien Chen, Chiang-Ching Huang, Tsao-Chuen Chung, Rouh-Mei Hu, Yi-Wei Huang, Tsuey-Ching Yang*. 2011. Contribution of resistance-nodulation-division efflux pump operon smeU1-V-W-U2-X to multidrug resistance of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 55:5826-5833. (Corresponding author)
  27. Cheng-Wen Lin, Hsin-Chieh Lin, Yi-Wei Huang, Tung-Ching Chung, Tsuey-Ching Yang*. 2011. Inactivation of mrcA gene derepresses the basal-level expression of L1 and L2 beta-lactamases in Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy 66:2033-2037. (Corresponding author)
  28. Yi-Chin Chang, Mei-Jung Tsai, Yi-Wei Huang, Tung-Ching Chung, Tsuey-Ching Yang*. 2011. SmQnrR, a DeoR-type transcriptional regulator, negatively regulates the expression of Smqnr and SmtcrA in Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy 66:1024-1028. (Corresponding author)
  29. Tsuey-Ching Yang, Me-Jung Tsai, Jeffrey, J. P. Tsai, Rouh-Mei Hu*. 2011. Induction of a secretable beta-lactamase requires a long lag time in Xanthomonas campestris pv. Campestris str. 17. Research in Microbiology 162:999-1005. (First author)
  30. Yi-Wei Huang, Rouh-Mei Hu, Yu-Ting Chiang, Tsao-Chuen Chung, Tung-Ching Chung, Tsuey-Ching Yang*. 2011. Establishment of an arabinose-inducible system in Stenotrophomonas maltophilia. Folia Microbiologica 56:18-22. (Corresponding author)
  31. Yi-Wei Huang, Cheng-Wen Lin, Rouh-Mei Hu, Yu-Tzu Lin, Tung-Ching Chung, Tsuey-Ching Yang*. 2010. An AmpN-AmpG operon is essential for the expression of L1 and L2 beta-lactamases in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 54:2583-2589. (Corresponding author)
  32. Yi-Chih Chang, Yi-Wei Huang, Kai-Hung Chiang, Tsuey-Ching Yang*, Tung-Ching Chung*. 2010. Introduction of an AmpR-L2 intergenic segment attenuates the induced beta-lactamase activity of Stenotrophomonas maltophilia. European Journal of Clinical Microbiology and Infectious Disease 29:887-890. (Corresponding author)
  33.  Tsuey-Ching Yang, Chien-Chen Lai, Su-LianShiu, Pei-Hsin Chuang, Bo-Cheng Tzou, Ying-Ya Lin, Fuu-Jen Tsai, Cheng-Wen Lin*. 2010. Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38MAPK activation in human promonocyte cells. Microbes and Infection 12:643-651. (First author)
  34. Ping-Ning Hsu*, Tsuey-Ching Yang*, Jung-Ta Kao, Ken-Sheng Cheng, Yi-Ju Lee, Yuan-Min Wang, Chin-Tung Hsieh, Cheng-Wen Lin, Yi-Ying Wu*. 2010. Increased PD-1 and decreased CD28 expression in chronic hepatitis B patients with advanced hepatocellular carcinoma. Liver International 30:1379-1386. (Corresponding author)
  35. Nai-Wan Hsiao, Jiun-Wei Chen, Tsuey-Ching Yang, Gregg M. Orloff, Yi-Ying Wu, Chih-Ho Lai, Yu-Ching Lan, Cheng-Wen Lin*. 2010. ISG15 over-expression inhibits the replication of Japanese encephalitis virus in human medulloblastoma cells. Antiviral Research 85:504-511.
  36. Tsuey-Ching Yang*, Yi-Wei Huang, Rouh-Mei Hu, Shao-Cheng Huang, and Yu-Tzu Lin. 2009. AmpDI is involved in expression of chromosomal L1 and L2 b-lactamases of Stenotrophomonas maltophiliaAntimicrobial Agents and Chemotherapy 53:2902-2907. (Corresponding author)
  37. Tsuey-Ching Yang, Yu-Wei Leu, Hui-Chen Chang-Chien, Rouh-Medi Hu*. 2009. Flagellar biogenesis of Xanthomonas campestris requires alternative sigma factors RpoN2 and FliA, and temporally regulated by FlhA, FlhB and FlgM. Journal of Bacteriology 191:2266-2275. (First author)
  38. Cheng-Wen Lin, Yi-Wei Huang, Rouh-Mei Hu, Kai-Hung Chiang, Tsuey-ChingYang*. 2009.  The role of AmpR in the regulation of L1 and L2 beta-lactamases in Stenotrophomonas maltophilia. Research in Microbiology 160:152-158. (Corresponding author)
  39. Rouh-Mei Hu, Kai-Hung Chiang, Yi-Chih Chang, Tsuey-Ching Yang*.  2009. Characterization of the charge variants of L2 beta-lactamase in Stenotrophomonas maltophilia. Journal of Medical Microbiology 58:318-321. (Corresponding author)
  40. Tsuey-Ching Yang, Chun-Pin Chang, Yu-Ching Lan, Chao-Li Liu, Mu-Chin Shih, Fang-Yang Wu, Cheng-Wen Lin. 2009. Recombinant ORF66 and ORFK12 antigens for the detection of human herpesvirus 8 antibodies in HIV-positive and –negative patients. Biotechnology Letters 31:629-637. (First author)
  41. Tsuey-Ching Yang, Su-Lian Shiu, Pei-Hsin Chuang, Ying-Ju Lin, Lei Wan,Yu-Ching Lan, Cheng-Wen Lin*. 2009. Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells. Virus Research 143:77-85. (First author)
  42. Rouh-Mei Hu, Kuang-Jay Huang, Lii-Tzu Wu, Ying-Ju Hsiao, Tsuey-Ching Yang*. 2008. Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy. 52:1198-1200. (Corresponding author)
  43. Su-Hua Huang, Tsuey-Ching Yang, Ming-Hong Tsai, I-ShouTasi, Huang-ChihLu, Pei-Hsin Chuang, Lei-Wan, Ying-Ju Lin, Chih-Ho Lai, and Cheng-Wen Lin. 2008. Gold nanoparticle-based RT-PCR and real-time quantitative RT-PCR assays for detection of Japanese encephalitis virus. Nanotechnology. 19:pp405101.
  44. Cheng-Wen Lin, Rouh-Mei Hu, Shao-Cheng Huang, Ying-Ju Hsiao, Tsuey-Ching Yang*. 2008.  Induction potential of clavulanic acid toward L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. European Journal of Clinical Microbiology & Infectious Disease 27:1273-1275. (Corresponding author)
  45. Rouh-Mei Hu, Kai-Hung Chiang, Cheng-Wen Lin, Tsuey-Ching Yang*. 2008. Modified nitrocefin-EDTA method to differentially quantify the induced L1 and L2 beta-lactamase in Stenotrophomonas maltophilia. Letters in Applied Microbiology 47:457-461. (Corresponding author)
  46. Cheng-Wen Lin, Chien-Shun Chiou, Yi-Chih Chang, Tsuey-Ching Yang*. 2008. Comparison of pulsed-field gel electrophoresis and three rep-PCR methods for evaluating the genetic relatedness of Stenotrophomonas maltophiliaisolates. Letters in Applied Microbiology 47:393-398. (Corresponding author)
  47. Cheng-Wen Lin*, Chieh-Wen Cheng, Tsuey-Ching Yang, Shih-Wein Li, Mei-Hsiu Cheng, Lei Wan, Ying-Ju Lin, Chih-Ho Lai, Wei-Yong Lin, Ming-Ching Kao. 2008. Interferon antagonist function of Japanese encephalitisvirus NS4A and its interaction with DEAD-box RNA helicase DDX42. Virus Research 137:49-55.
  48. Yi-Ming Hsiao, Mei-Huei Zheng, Rouh-Mei Hu, Tsuey-Ching Yang, Yi-Hsiung Tseng*. 2008. Regulation of pehA gene encoding the major polygalacturonase of Xanthomonas campestris by Clp and RpfF. Microbiology-SGM 154:705-713.
  49. Tsuey-Ching Yang, Rouh-Mei Hu, Shu-Fu Weng, and Yi-Hsiung Tseng*. 2007. Identification of a hypothetical protein of plant pathogenic Xanthomonas campestrisas a novel beta-galactosidase. Journal of Molecular Microbiology and Biotechnology 13:172-180.
  50. Lii-Tzu Wu, Shu-Ying Chang, Ming-Ren Yen, Tsuey-Ching Yang, Yi-Hsiung Tseng*. 2007. Characterization of extended-host-range pseudo-T-even bacteriophage Kpp95 isolated on Klebsiella pneumoniae. Applied and Environmental Microbiology 73:2532-2540.
  51. Rouh-Mei Hu, Tsuey-ChingYang, Shu-Hui Yang, Yi-Hsiung Tseng*. 2005. Deduction of upstream sequence of Xanthomonas campestris flagellar genes responding to transcription activation byFleQ. Biochemical and Biophysical Research Communications 335:1035-1043.
  52. Yi-Min Hsiao, Hsiu-Ying Liao, Mong-Chuan Lee, Tsuey-Ching Yang, Yi-Hsiung Tseng*.2005. Clp upregulates transcription of engA gene encoding a virulence factor in Xanthomonas campestris by direct binding to the upstream tandem Clp sites. FEBS Letters 579:3525-3533.
  53. Tsuey-Ching Yang, Rouh-Mei Hu, Yi-Min Hsiao, Shu-Fen Weng, Yi-Hsiung Tseng*. 2003. Molecular genetic analyses of potential b-galactosidase genes in Xanthomonas campestris. Journal of Molecular Microbiology and Biotechnology 6:145-154. (First author)
  54. Tsuey-Ching Yang, Gong-Ho Wu, Yi-Hsiung Tseng*. 2002. Isolation of a Xanthomonas campestris strain with elevated b-galactosidase activity for direct use of lactose in xanthan gum production. Letters in Applied Microbiology 35:375-379.